In order to study the lipid-lowering effect of compound tea， the high-fat mice model was established by high-fat diet. Based on the method of UPLC-MS/MS detection platform， multivariate statistical analysis and self-built database， the difference degree of metabolism group among samples was studied. In this experiment， the normal model group (CK)， high-fat diet group (NK) and compound tea group (DH) were set up， and the Xuezhikang capsule was used as the positive drug group (YK) to compare the effects of compound tea on the metabolism of amino acids in the liver of hyperlipidemic mice. The results showed that a total of 13 amino acid metabolites such as L-homocystine， N-acetylmethionine， D-alanyl-D-alanine， S-adenosylmethionine， L-asparagine and L-tyrosine methyl ester in the liver of mice induced by high-fat diet showed a downward trend， which were significantly enriched in the cysteine and methionine metabolism after the intervention of compound tea. Compared with the YK group， only five of amino acid metabolites such as N-acetylaspartate， N-isovaleric acid and alanine were significantly down-regulated after treatment of Xuezhikang. These fundings indicated that compound tea had a certain regulatory effect on liver amino acid metabolites and pathways in hyperlipidemia mice， which effect was better than the positive drug Xuezhikang. The purpose of this study is to explore the mechanism of reducing lipid of amino acids and their derivatives in compound tea by using metabonomics technology， and to provide some reference for the development and utilization of compound tea.