At present， the market supervision department actively promoted the implementation of "territorial management responsibility" and "enterprise's main body responsibility" for food safety， and strictly prevented and controlled food safety risks. Therefore， in order to guide and supervise food enterprises to apply scientific and effective methods to implement the main body responsibility of food safety， learn from and transform international food safety standards， and comprehensively promote the application of food safety prevention and control measures based on hazard analysis and critical control point (HACCP) principle is imperative. This article systematically analyzes the application of HACCP system， investigates the measures taken by local food regulatory departments to promote the application of HACCP and adopt HACCP related certification， concludes the benefits of applying HACCP principles to prevent and control food safety risks， as well as summarizes the problems and challenges in the application of HACCP. In addition， based on the actual situation of China， this paper puts forward relevant suggestions on the development of HACCP from four aspects: standard revision， talent training， scientific and technological support， and innovation of supervision mode. To provide theoretical support for improving the scientific and systematization of food safety risk screening and prevention and control of food producers and operators， and improving the government regulatory governance mechanism and system construction.