典型链格孢霉毒素的污染现状与毒理学性质研究进展
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(1.西南大学食品科学学院 重庆 400715;2.川渝共建特色食品重庆市重点实验室 重庆 400715)

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国家自然科学基金项目(32001810,32072137,CSTB2022NSCQ-MSX1157)


Advanced Progress in Contamination Status and Toxicological Properties of Typical Alternaria Toxins
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(1.College of Food Science, Southwest University, Chongqing 400715;2.Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Chongqing 400715)

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    摘要:

    链格孢霉毒素是链格孢霉菌产生的次级代谢产物,在谷物、果蔬、坚果、油料作物等农作物和农产品中污染广泛,对人和动物有不同程度的急性毒性、遗传毒性、生殖发育毒性等,然而,现有的污染水平、膳食暴露量及毒效应等资料有限且研究系统性不强,安全风险评估的理论支撑薄弱。基于此,本文系统梳理了典型链格孢霉毒素的污染现状及其毒理学性质,旨在为进一步评估其暴露水平,开展安全性评价,科学制定限量标准与法规提供较为全面、系统的理论依据。

    Abstract:

    Alternaria toxins, as the secondary metabolites produced by Alternaria species, are widely contaminated in crops and agricultural products such as cereals, fruits, vegetables, nuts, oil crops, etc., which shows different degrees of acute toxicity, genetic toxicity, reproductive and developmental toxicity to humans and animals. However, the available studies of its contamination level, dietary exposure and toxic effects are still relatively limited and short of systematization, which making it difficult to carry out a comprehensive risk assessment. Therefore, this review systematically demonstrated the contamination status and toxicological profiles of typical alternaria toxins, aiming to provide a more comprehensive and systematic theoretical basis for the further assessment of exposure level of alternaria toxins, comprehensive safety evaluation, and scientific formulation of limit standards and regulations.

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杨玉莲,周鸿媛,刘虫虫,张宇昊,马良.典型链格孢霉毒素的污染现状与毒理学性质研究进展[J].中国食品学报,2023,23(3):376-389

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  • 收稿日期:2022-06-08
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  • 在线发布日期: 2023-04-06
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