The drying method has great influence on the physicochemical properties of resistant lotus root powder. In order to study the effect of spray drying synergistic enzymatic preparation on resistant lotus root powder， lotus root powder was used as raw material to prepare resistant lotus root by using pressure-heat cooling cycle， spray drying synergistic high temperature resistant α-amylase and pullulanase， respectively. The modification effects of different methods were compared by the yield， texture， rehydration， microstructure and infrared spectrum characteristics. The results showed that the yield of resistant lotus root powder prepared by spray drying synergistic pullulanase was 5.3%， which was significantly higher than other treatment groups (P < 0.05)， while the yield by spray drying synergistic α-amylase was second highest (4.6%) and pressure-heat cooling cycle was the lowest (2.7%). Spray drying synergistic enzymatic could decrease the hardness， elasticity， adhesion and cohesion of lotus root powder. The particles prepared by enzymatic hydrolysis were rough， with obvious cracks and larger particles， while the particles prepared by spray drying synergistic enzymatic were uniform and delicate with smooth surface. Compared with the original lotus root powder， spray drying synergistic preparation could narrow the characteristic absorption peaks (3 500-3 200 cm-1) and shift the peak (990 cm-1). Therefore， spray drying synergistic enzymatic could increase the amorphous area， reduce the branching chains and reduce the viscosity， and make the lotus root powder have better resistance and flushing property.