Objective: To investigate the chemical constituents and antioxidant activity from Citrus reticulate Blanco superior plants fruit peel， and explore the potential effect about it. Methods: To study the chemical constituents of Citrus reticulate Blanco superior plants fruit peel by using HPLC-DAD-ESI-MS/MS and GC-MS， evaluation of their antioxidant activity by DPPH method， ABTS method， ferric reducing antioxidant power (FRAP) and measurement of lipid peroxidation by thiobarbituric acid reactive substances methods (TBARS). Targets related to antioxidant were screened by Network pharmacology， and used for GO functional and KEGG enrichment pathway analysis and construct the network of active ingredients-targets-pathway by Cytoscape 3.8.2， and molecular docking was used to verify the interactions between the main active ingredients and the key targets of Citrus reticulate Blanco superior plants fruit peel. Results: The HPLC-DAD-ESI-MS/MS results showed that 32 compounds and GC-MS results showed that 33 volatile components were identified of Citrus reticulate Blanco superior plants fruit peel. In vitro antioxidant experiments showed that has significant antioxidant capacity. The network pharmacology and molecular docking results showed that the flavonoid components such as Naringenin and TP53， MAPK3 and other targets matched well. Conclusion: This study initially explored the potential mechanisms of multi-component， multi-target and multi-pathway antioxidant intervention of Citrus reticulate Blanco superior plants fruit peel， providing new possibilities for the further development about it as functional food ingredients or functional feed.