‘Healthy China 2030’ has become a national strategy， and the development of the food and nutrition health industry holds significant importance in improving the overall nutritional health of the population. The nutritional functionality of food in the human body largely depends on its process of digestion and the resulting products. Due to ethical restrictions on human research， in vitro simulation of human gastrointestinal digestion and fermentation has become a crucial technical issue for food nutrition research. This achievement combines the principles of human gastrointestinal digestion and fermentation， comprehensive simulation， and artificial intelligence. It establishes the basis for the construction of the simulation device based on the physiological characteristics of the human gastrointestinal environment from the oral cavity to the stomach， small intestine， and large intestine. It has independently designed and completed core simulation components such as digestion/fermentation tanks， gastrointestinal emptying devices， digestive fluid secretion devices， absorption devices， and established key simulation technology for gastrointestinal digestion， fermentation， and absorption. It has also constructed an AI intelligent system for simulating， sampling， monitoring， and warning any part of the gastrointestinal tract， combined with centralized control devices to achieve automatic simulation of the digestion， fermentation， and absorption process， breaking through the bottleneck of intelligent control technology. Based on the aforementioned key technologies， it has achieved the full process simulation of oral cavity - stomach - small intestine - large intestine， and can systematically verify animal or clinical trial results. With the device， an evaluation technical system for gastrointestinal digestion and metabolism of different food nutrients was established， uncovering various modes of digestion and metabolism for different food nutrients， and facilitating the formulation of optimized products. This contributed to the development and industrialization of a series of new health products， in support of the national strategy of‘Healthy China 2030’， and was selected as one of the Top Ten Advances in Chinese Food Science and Technology in 2022.