Objective: This experiment was conducted to investigate the hypoglycemic effect of polyphenol extract from germinated mung bean on type 2 diabetic mice and the effect on intestinal flora of mice. Methods: According to the weight of C57BL/6 mice， they were randomly divided into normal group， T2DM model group， positive control group， and low (50 mg/kg)， medium (100 mg/kg) and high (150 mg/kg) dose group of germinated mung bean polyphenols extract. A model of type 2 diabetic mice was established by high fat diet combined with intraperitoneal injection of streptozotocin (STZ). After 5 weeks of intragastric administration， fasting blood glucose (FBG)， glucose tolerance， insulin (INS)， and the concentrations of inflammatory cytokines interleukin IL-6， IL-10， tumor necrosis factor (TNF-α) and C-reactive protein (CRP) were determined. The feces of mice were collected. The 16S rRNA platform was used to carry out high-throughput sequencing to detect the changes of intestinal flora in diabetic mice under the intervention of polyphenol extract. Results: Germinated mung bean polyphenol extract could significantly reduce fasting blood glucose， improve glucose tolerance and reduce insulin resistance in T2DM mice. The levels of IL-6， TNF-α and CPR were significantly decreased， and the levels of IL-10 were increased， thus alleviating the inflammatory response caused by diabetes. Repair mouse liver tissue cell morphology. Regulate flora abundance and species diversity to improve the dysfunctional intestinal flora. Conclusion: The polyphenol extract of germinated mung bean can improve the type 2 diabetes in mice by reducing the inflammatory response and regulating the abundance of intestinal flora.