To enhance the stability of collagen peptide from squid skin， taking the embedding rate and yield of the product as indicators， the optimal process of preparing collagen peptide microcapsules by spray drying was optimized through single factor and response surface experiments， and the physicochemical properties and stability of the microcapsules were also analyzed. The results showed that with microporous starch as the adsorption carrier and arabic gum as the wall material， the optimum conditions for the preparation of microcapsules were air inlet temperature 173 ℃， core to wall ratio 1∶4， solid content 17%. Under these conditions， the embedding rate and the sample yield of squid skin collagen peptide was (74.65±0.05)% and (72.32±0.16)% respectively. The prepared microcapsules had low water content， good solubility， high acceptability and strong thermal stability. Squid skin collagen peptide had a certain slow-release effect after microencapsulation， and its digestive stability was also improved. This study provides a theoretical basis for improving the level of intensive processing and comprehensive utilization of squid resources.