无花果超微粉研制及改善便秘功效研究
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(1.西北农林科技大学食品科学与工程学院 陕西杨凌 712100;2.陕西丝路无花果科技研究院有限公司 西安 710000;3.西北农林科技大学深圳研究院 广东深圳 518000;4.西北农林科技大学化学与药学院 陕西杨凌 712100)

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科技创新2030“脑科学与类脑研究”重大项目(2022ZD0208100);中国博士后科学基金第72批面上资助(2022M72261);国家自然科学基金青年科学基金项目(82103842)


The Development of Fig Fruit Microcapsule Powder and Its Efficacy in Alleviating Constipation
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(1.College of Food Science and Engineering, Northwest Agriculture & Forestry University, Yangling 712100, Shaanxi;2.Shaanxi Silk Road Fig Science and Technology Research Institute Co., Ltd., Xi'an 710000;3.Northwest A&F University Shenzhen Research Institute, Shenzhen 518000, Guangdong;4.College of Chemistry and Pharmacy, Northwest Agriculture & Forestry University, Yangling 712100, Shaanxi)

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    摘要:

    便秘是一种由多种病理、病因引起的临床常见症状。通过饮食干预等方式调节肠道健康状态,是便秘治疗的有效措施。以无花果为原料,将果实制备为超微粉,将果渣制备为膳食纤维粉,并进行动物实验,探究其改善便秘的功效。结果显示:制备的果实超微粉(UFPD)总酚含量为(0.3015 ± 0.0184)mg/g;果渣膳食纤维粉(DF)的总膳食纤维含量为52.6%。使用两部分加工得到的超微粉分别干预便秘小鼠,与模型组相比均可显著提高小鼠的粪便含水量(P<0.01),增强肠道推进率(P<0.05),显著增加3 h排便量(P<0.05)。超微粉干预还可显著改善结肠组织结构,促进结肠紧密连接相关基因ZO-1的表达(P<0.05),降低促炎因子IL-6、IL-1β和TNF-α的mRNA表达水平(P<0.01),且血清神经递质Substance P(SP)含量相较于模型组显著增加(P<0.05)。上述结果表明,无花果超微粉加工方式可以保护多酚类物质和膳食纤维。无花果超微粉改善小鼠便秘可能是通过保护肠屏障完整性,抑制炎症和调节神经递质水平而发挥作用的。研究结果为无花果营养成分的保护及改善肠道相关疾病提供理论参考。

    Abstract:

    Constipation is a common clinical symptom caused by various pathological factors, and improving intestinal health through dietary interventions plays a significant role in the treatment of constipation. Using figs as the raw material, making fig microcapsule fruit powder and verifying the efficacy through animal experiments. The results showed that the total phenolic content of prepared ultra-micro fig fruit powder (UFPD) was (0.3015±0.0184) mg/g, and the total dietary fiber content of the dietary fiber group (DF) was 52.6%. Interventions with UFPD and DF effectively increased dejecta moisture content in constipated mice (P<0.01), enhanced intestinal propulsion rate (P<0.05), and significantly improved the fecal output of constipated mice within 3 hours (P<0.05). Fig fruit microcapsule powder interventions effectively alleviated colon damage in constipated mice, promoted the expression of colon tight junction-related gene ZO-1 (P<0.05), and reduced the expression of pro-inflammatory factors IL-6, IL-1β and TNF-α(P<0.01). Additionally, the content of serum excitatory neurotransmitter(Substance P) in the UFPD and DF groups was significantly higher than in the model group (P<0.05). The research results indicate that the ultra-micro fig microcapsule fruit powder process effectively preserves polyphenols and dietary fiber from figs. Fig fruit microcapsule powder can effectively improve the constipation in mice, possibly by protecting intestinal barrier integrity, inhibiting inflammation, and regulating neurotransmitter levels. This study aims to provide theoretical references for the protection of fig nutritional components and the improvement of intestinal-related diseases.

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丁辰,何颖,刘琳文,郭瑞,原田,刘志刚.无花果超微粉研制及改善便秘功效研究[J].中国食品学报,2025,25(3):167-177

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  • 收稿日期:2024-03-12
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  • 在线发布日期: 2025-05-23
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