膳食纤维经肠-脑轴改善阿尔兹海默症的研究进展
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(1.郑州轻工业大学食品与生物工程学院 郑州 450001;2.冷链食品加工与安全控制教育部重点实验室(郑州轻工业大学) 郑州 450001;3.西北农林科技大学食品科学与工程学院 陕西杨凌 712100;4.陕西省精准营养与健康研究院 西安 710300;5.昭通学院 化学化工学院 云南昭通 657000)

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国家自然科学基金项目(32472351);云南省教育厅科学研究基金项目(2024J1054);陕西省干旱地区农业实验室项目(2024ZY-JCYJ-02-44)


Research Progress on Dietary Fiber Improving Alzheimer's Disease via the Gut-brain Axis
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(1.College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450001;2.Key Laboratory of Cold Chain Food Processing and Safety Control (Zhengzhou University of Light Industry),Ministry of Education, Zhengzhou 450001;3.College of Food Science and Engineering, Northwest A&F University, Yangling 712100 Shaanxi;4.Shaanxi Precision Nutrition and Health Research Institute, Xi'an 710300;5.School of Chemistry and Chemical Engineering, Zhaotong University, Zhaotong 657000, Yunnan)

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    摘要:

    阿尔茨海默病(AD)是痴呆症中最常见的类型,目前尚无特效药物能够治愈或有效逆转其进展。饮食干预作为一种安全且应用广泛的干预策略,正受到越来越多的关注。大量研究表明,膳食纤维,尤其是可溶性膳食纤维(SDF),可以改善与AD病理相关的神经炎症。肠-脑轴作为连接胃肠道和中枢神经系统的关键通路,其核心组成部分——肠道菌群,被认为是饮食调节大脑健康的关键机制。本文概述膳食纤维,尤其是SDF,如何通过重塑肠道菌群来影响AD相关生理过程,其主要机制包括调节关键代谢产物、免疫通路、内分泌通路和迷走神经通路。当前相关研究虽存在一定的局限性,但现有研究结果充分表明,富含膳食纤维的饮食在维持认知健康方面具有显著潜力。这些发现也为食品产业开发以认知健康为导向的功能性食品提供了重要的理论支持。未来,基于膳食纤维与肠-脑轴的研究成果,有望推动食品原料利用、配方优化以及益生元协同应用方面的创新,为健康老龄化和大脑健康领域的食品研发与市场拓展提供新的思路。

    Abstract:

    Alzheimer's disease (AD) is the most common type of dementia, and there is currently no specific medication that can cure or effectively reverse its progression. Dietary intervention, as a safe and widely applicable strategy, has attracted increasing attention. Numerous studies have demonstrated that dietary fiber, particularly soluble dietary fiber (SDF), can alleviate neuroinflammation associated with AD pathology. The gut-brain axis, a critical communication pathway connecting the gastrointestinal tract and the central nervous system, with its core component-the gut microbiota-is considered a key mechanism through which diet modulates brain health. This review summarized how dietary fiber, especially SDF, modulates AD-related physiological processes by reshaping the gut microbiota. The main mechanisms included the regulation of key metabolites, immune pathways, endocrine pathways, and vagus nerve signaling. Although current research still had certain limitations, existing evidence strongly suggested that diets rich in dietary fiber hold significant potential for maintaining cognitive health. These findings also provide important theoretical support for the food industry in developing functional foods aimed at promoting cognitive well-being. In the future, research on dietary fiber and the gut-brain axis was expected to drive innovations in food ingredient utilization, formulation optimization, and the synergistic application of prebiotics. This will offer new opportunities for food research and development and market expansion in the fields of healthy aging and brain health.

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胡欣雨,贾梦真,余平莲,牛力源,刘志刚.膳食纤维经肠-脑轴改善阿尔兹海默症的研究进展[J].中国食品学报,2026,(2):425-440

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  • 收稿日期:2025-10-17
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  • 在线发布日期: 2026-04-03
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