Furan， a typical food contaminant generated during the heating of foods， is harmful to the health. In this study， we discussed the antioxidant activity of naringin and its effects on furan-induced toxicity. Fifty male Balb/c mice were randomly divided into five groups（control group， furan-treated group and three naringin-treated groups with the concentration of 5， 10， 20 mg/kg/d， respectively）. Protective effects of naringin on furan-induced toxicity were evaluated by determining the ROS content， oxidative damage， cytokine levels， DNA damage， and the liver and kidney damage in a mouse model. The results showed that furan induced the kidney and liver of mice different degrees of damage. Compared with the furan-treated group， naringin mitigated the oxidative damage induced by furan by increasing GST， GSH and SOD activities but decreasing MPO and MDA content. On the other hand， naringin could decrease cytokine levels of IL-1β， IL-6， IL-10 and TNF-α in the serum of furan treated mice. At the same time， naringin could decrease the ROS content， 8-OHdG， the liver and kidney damage indexes of AST， ALT， LDH， BUN and creatinine. Conclusion： naringin， as a kind of antioxidant， has a certain protective effects on the liver and kidney injury of the mice induced by furan， while 10 mg/kg/d of naringin-treated group was the most obviously concentration on furan induced toxicity.