Abstract:The nanostructured lipid carrier(RL-NLC) was developed to encapsulate, protect and deliver resveratrol and linseed oil by the hot high pressure homogenization technology. The microstructure, physicochemical stability, antioxidant activity, in vitro release, accelerated lipid oxidation and other characteristics were analyzed. The particle size of RL-NLC was about 105 nm and the PDI was about 0.216. The spherical nanoparticles could be well dispersed in aqueous and could be stored for more than 3 months at 25 ℃ without light. Encapsulated resveratrol had better antioxidant activity and slower release rate in vitro than free resveratrol. In addition, it was found that the presence of the solid lipid core and resveratrol inhibited the oxidation of linseed oil in an accelerated storage experiment at 50 ℃. The carrier loaded resveratrol and linseed oil developed in this paper may have a good application prospect in the field of functional foods.