The effect of different spray-drying temperature （130 ℃/65 ℃， 160 ℃/78 ℃， 180 ℃/90 ℃） on the physicochemical property and structure of micellar casein powder （MCP） have been investigated. The results showed that the microstructure change was insignificant and the flow index was good at temperature of 130 ℃/65 ℃. As the increase of spray drying temperature from 130 ℃/65 ℃ to 180 ℃/90 ℃， the MPC surface become rough， the D50 of MCP reduced from 14.13 μm to 10.47 μm， the solubility of MCP reduced from 84.14% to 60.44%， the moisture content reduced from 4.07% to 3.20%， and the flow index reduced from 4.16 to 1.27. In generally， 130 ℃/65 ℃ was proper temperature of spray drying.