A QuEChERS pretreatment coupled to liquid chromatography-quadrupole-time of flight mass spectrometry （LC-Q-TOF-MS） method was established for identification and quantification of 24 illicit anti-inflammatory and sedative drugs in the health food. The illicit drugs in samples were accepted with the QuEChERS， comparing with the solvent extraction. The quantitative analysis was based on the accurate mass of protonated/ deprotonated molecular ion， isotopic pattern， a priori known retention time， and high resolution fragment ion spectrum with information dependent acquisition. The result showed that the established LC-Q-TOF-MS was an effective analytical method for the simultaneous characterization and quantification of anti-inflammatory and sedative drugs with high selectivity， a high linearity （r2>0.999） in wide range， low LOD and LOQ， and high recoveries （81.8%-103%）。