Objective： To investigate the effects of enteral nutrition in Perinereis aibuhitensis on nutrition metabolism and inflammation of mice with precancerous lesions. Methods： The mice model of precancerous lesions were induced and prepared with diethylnitrosamine， and then clamworm treatment group 1（A）， clamworm treatment group 2（B）， clamworm treatment group 3 （C）， a positive control group （D）， a blank group （E） and a control group （F） were set up. The plasma nutrition index， inflammation index and liver function index were detected after the blood sampling of D7， D14， D21 and D28 respectively. Finally， the hepatic pathological changes were observed. Result： The weight of mice increased gradually during the treatment of enteral nutrition in Perinereis aibuhitensis. For D28， the weight of group A was 61.49% higher than group E； The contents of TP and Alb of group A were significantly higher than group E， while lower than F group. Group A increased by 30.32% and 13.68% separately. For D7， D14， D21 and D28， the TNF-α level of group A was obviously lower than group E. For D28， group A decreased by 30.15% when compared with group E； Group A had a significantly higher level of IL-2 than group E. For D7， D14， D21 and D28， the ALT and AST levels of group A markedly decreased compared with group E. For D 28， group A were 83.75% and 128.20% lower respectively. Group A had good histological features of liver tissue compared with group E. Conclusion： When Perinereis aibuhitensis was used as protein source of enteral nutrition， the special medical purpose formula can promote the synthesis of TP and Alb in the liver of precancerous lesions of experimental animals， and improve the nutritional metabolism of liver precancerous lesions in mice. It can also relieve the inflammation of TNF-α， IL-2 in liver precancerous lesions experimental animals， as well as the liver tissue morphological damage reflected by ALT and AST. When the protein content of silkworm was 60% of the total protein of enteral nutrition， the nutritional effect of the Perinereis aibuhitensis enteral nutrition formula was significant.