Abstract:A simple analytical method for the determination of 22 kinds of trace elements in edible vegetable oil was established by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). The edible vegetable oil samples were diluted with kerosene and then directly injected for analyzing. In the MS/MS mode, H2, O2, and NH3/He were used as the reaction gas, with whom the interferences or analytes will react, as a result the mass spectrometry interferences were eliminated by on-mass method or mass-shift method. The analytes showed good linearity with linear correlation coefficient ≥ 0.9996, and the detection limit was 0.35-307.84 pg/g. The accuracy of the method was verified by spiked recovery experiment. The spike recoveries ranged from 96.60% to 105.46%, and the relative standard deviation (RSD) is ≤ 3.99%. The edible vegetable oil, such as rapeseed oil, peanut oil, sunflower oil, corn oil and olive oil, from different parts of China were determined by this established method. The results reveal that the contents of P, S, K, Na and Ca in the five kinds of edible vegetable oil were higher, while the contents of As, Cd, Hg and Pb were low. The analytical method has the characteristics of simple sample processing, high sensitivity and low detection limit, and can accurately monitor the nutritive elements and heavy elements in edible vegetable oil.