In order to improve the growth retardation caused by zinc deficiency， the zinc-sulfated oligosaccharide was produced by polysaccharides extracted from eucheuma. The improving effects of growth and development by zinc-sulfated oligosaccharide， zinc gluconate and zinc sulfate were compared. The dosage of zinc gluconate group and zinc sulfate group was 6.96 mg Zn/kg bw， and the dosages of zinc-sulfated oligosaccharide in low， medium and high dose group were 1.74， 3.48 and 6.96 mg Zn/kg bw， respectively. The growth and development of the mice were analyzed by food intake， body weight， the zinc contents and the activity of AKP in serum and liver， and the weights of liver， kidney， brain and testis. The antioxidant effects were expressed by MDA， SOD and T-AOC in the liver. The results showed that zinc-sulfated oligosaccharide could increase food intake， body weight， the zinc contents and the activity of AKP， the weights of liver， kidney， brain and testis， which exhibited good growth and development. On the other hand， higher activity of SOD and T-AOC and lower content of MDA indicated desirable antioxidant. The effect of medium dose of zinc-sulfated oligosaccharide was similar to that of zinc gluconate， and the effect of high dose was significant higher than that of the same dose of zinc gluconate， zinc sulfate.