The polyphenol compounds from azuki bean coats （Vigna angularis） were extracted by ultrasonic-assisted extraction. Response surface methodology was used to optimize the process parameters of ethanol concentration， ultrasound power， ultrasound time and liquid to solid ratio. The optimum technological parameters of ultrasonic extraction for azuki bean coat polyphenols were： ethanol concentration 60%， ultrasound power 360 W， ultrasound time 30 min and liquid to solid ratio 30 ∶ 1（mL/g）， which the polyphenols extraction were（145.28 ± 2.21） mg/g. The azuki bean coat polyphenols were determined by high performance liquid chromatography for 13 monomer phenolics： gallic acid， rutin， catechin， chlorogenic acid， proanthocyanidin B2， epicatechin， ferulic acid， isovitexin， vitexin， isorhamnetin， hyperoside， kaempferol， quercetin. The antioxidant test results showed that the 1，1-diphenyl-2-picrylhydrazyl （DPPH） free radicals， superoxide free radical scavenging capacity of the azuki bean coat polyphenols were slightly lower than VC， 2，2'-azino-bis（3-ehtylbenzothiazoline-6-sulfonic acid） diammonium salt radical （ABTS+·） free radicals， hydroxyl radical scavenging capacity were higher than VC， demonstrated that the polyphenol compounds extracted from the azuki bean coats has strong antioxidant activity and were great potential natural antioxidants for the development.