Artemisia selengnesis Turcz （AST） is a special food resource of Jiangxi province， and the tender stems of it are often processed into delicious food， but their leaves and root are discarded as directly. This study compared the content of phenolics and flavonoids， antioxidant activity， acetylcholinesterase inhibition， α-glucosidase and xanthine oxidase inhibition of wild and cultivated AST leaves， stems and wild AST root， to aim to provide information for high value utilization of by-products of AST. The results showed that wild and cultivated AST leaves had the higest phenolics （30.12 mg GAE/g DM） and flavonoids （0.63 mg QuE/g DM）， respectively. What’s more， wild AST leaf extract gave the strongest DPPH· scavenging ability， ABTS+· scavenging ability and acetylcholinesterase inhibition， the IC50 value was 0.37， 0.39 and 4.01 mg DM/mL， respectively. The strongest α-glucosidase and xanthine oxidase inhibition was observed in wild AST root extract with the IC50 values of 14.08 and 4.01 mg DM/mL， and the second is wild AST leaf. Correlation analysis indicated that phenolics was the major antioxidant components of AST. Thus， compered to cultivated AST and wild AST stems， wild AST leaves are more suitable as natural resourse of antioxidants， α-glucosidase， acetylcholinesterase and xanthine oxidase inhibitors， and there should have a further study on antidiabetic， anti-hyperuricemia， anti-Alzheimer’s disease effect of it.