Objective： This study was undertaken to determine the effectiveness of tea polyphenols （TP） in preventing cadmium chloride（CdCl2） induced hepatotoxicity and hematotoxicity in mice. Methods： Eight-week-old male Kunming mice were chosen. Control， Cd-treated （a single injection of 30 μmol/L Cd2+/kg， i.p.）， Cd + TP （after Cd treated， administered to mice daily for 5 days at 100 mg/kg， i.p.） and group of TP per se were used. Erythrocyte fragility， the influence on cellular biochemical components， lipid peroxidation level， morphological changes， the levels of cytosolic enzymes in serum， the extent of oxidative damage and levels of the key antioxidant enzymes in liver， and hepatic histopathology in mice were evaluated. Results： The levels of Cd（Ⅱ） in liver and blood， the activities of transaminases in serum and osmotic fragility were increased by comparison with the control， while the activities of superoxide dismutase and catalase decreased significantly in the Cd-treated group. However， treating mice with TP alleviate Cd-induced oxidative damaging effects， stabilize cell membrane， prevent the changes of hepatic histopathology. Conclusion： TP not only chelates with Cd， but also plays an antioxidant role to weaken the biotoxicity of CdCl2. TP supplementation may be favorable to avoid Cd-induced hematotoxicity and hepatotoxicity for humans.