The oil-in-water pickering emulsions stabilized with nanocellulose particles were prepared and the effect of cellulose concentration， oil volume， size of cellulose particles on the size， ζ-potential， microstructure and stability of emulsion were investigated. The results showed that with the increase of cellulose concentration， the more cellulose particles adsorbed on the surface of oil droplets and the particle size of emulsion gradually decreased linearly. The contact angle between cellulose and water increased with the increase of hydrolysis time， which showed a good hydrophilic performing wetting properties. There was a particle size effect between the particle size and its stable emulsion particles. The emulsion stabilized with cellulose particles at hydrolysis durations of 10 h had a smaller particle diameter with the cellulose concentration 0.9%， 1% oil. After a week， there was no obvious stratification of the emulsion and showed good stability. The results illustrated that cellulose can be used to build a stable emulsion system and to deliver the active ingredient or pharmaceutical ingredient.