Objective： Mung bean peptides（MBPs） were used in lipopolysaccharide（LPS）-induced macrophage RAW264.7 inflammatory response to observe whether the inhibition of the inflammation produced. Methods： Using LPS to establish cell inflammation model. Using WST-1 method to detect cell proliferation， Neutral Red method to detect phagocytosis， KIT method to detect macrophage myeloperoxidase（MPO）， lactate dehydrogenase（LDH） activity and reduced glutathione（GSH） content， ELISA to detect the levels of TNF-α， interleukin-1α（IL-1α） and interleukin-6（IL-6） in macrophages. Result： MBPs significantly attenuated the inhibitory effect of LPS on the proliferation of macrophages and down-regulated its phagocytosis（P<0.05）. MBPs could significantly improve the level of MPO， LDH and GSH in macrophages induced by LPS（P<0.05）. MBPs could significantly inhibit the increase of the levels of proinflammatory cytokines TNF-α， IL-1α， IL-6. Conclusion： MBPs could alleviate the LPS-induced macrophage inflammatory response by regulating the chemotactic phagocytosis of macrophages， intracellular digestion and digestion， and the decrease of proinflammatory cytokines levels， showing dose-response and anti-inflammatory activity.