Objective： In order to enable the reuse of waste algal meal after the extraction of DHA by microalgae Schizochytrium sp.， this project conducted studies on the efficacy of its enzymatic hydrolysis products to inhibit intestinal inflammation， and laid a solid experimental foundation for the application of its replacement of existing antibiotics. Method： Trypsin was used to hydrolyze the algal meal， and the peptide mixture（MESH） was obtained after dialysis. It was added to the feed containing vitamin AD. Grass carp and eel was used for freshwater farming and marine fish as representative test animal for constructing trinitrobenzenesulfonic acid（TNBS） enteritis model. Negative control group were used of equal volume phosphate buffer solution（PBS）， and positive control group were used antibiotic enrofloxacin. The test animals were dissected 1， 3 days and 7 days after infusion， respectively. The disease activity index scores， changes in myeloperoxidase （MPO） activity， and changes in intestinal pathological tissues were used to comprehensively assess the degree of fish enteritis. Results： After induction by TNBS， both MESH group and enrofloxacin group could prevent and treat the enteritis symptoms of grass carp and eel. Among them， the MESH group had more significant prevention and treatment effects on enteritis than the enrofloxacin group. Conclusion： Microalgae Schizochytrium sp. meal enzymatically active peptide MESH compound feed vitamin AD can effectively inhibit aquatic fish enteritis， and can replace the existing antibiotics used in enteritis.