The operation mode of the automatic food manufacture-sale vending machine has the characteristics of catering， circulation and production. It belongs to the new food business state， and it is very difficult to obtain the food business license because of the lack of corresponding regulations and standards. The study found that food safety assessment is a feasible approach. In this paper， the necessity of food safety assessment for the automatic food manufacture-sale vending machine is first introduced. And then the present situation of food safety assessment of the automatic food manufacture-sale vending machine is summarized. Finally， the methods and relevant laws and regulations of food safety assessment for the automatic food manufacture-sale vending machine are summarized， and the comprehensive theoretical reference is provided for the food safety assessment of the automatic food manufacture-sale vending machine.