This paper established a model of non-alcoholic fatty liver in Meriones unguieulataus （MU）， aiming to explore the effect of food derived nanoparticles （FNPs） from freshwater clam soup on non-alcoholic fatty liver disease （NAFLD）. Results showed that the levels of TC， TG， AST and ALT of MU exposed to high-fat diet for 4 weeks significantly rose （P﹤0.05）. Besides， the liver tissue of the high-fat group showed focal necrosis， demonstrating the successful modeling of the MU with NAFLD. Compared with the high-fat model group， the indexes of the MU fed with oral or gavage administration of FNPs decreased， among which TC in serum and liver and AST in the liver slumped（P﹤0.01）. The indexes in the liver were close to those of the normal control group. It suggested that the soup nanoparticles， whether oral or gastric administration for MU could effectively reduce hematic fat and intervene with nonalcoholic fatty liver disease. In addition， the effect of oral group was closer to normal and superior to gavage group. Oral administration may bestow the food nanoparticles the opportunity to directly interact with the digestive tract mucosa， so as to play a strong biological activity of hepatocyte protection.