In recent years， the commercialized application of bacteriophages in the fields of medicine， agriculture and food safety has been approved by many countries. However， there is no relative commercialized application with independent intellectual property in China. Since the abuse of the traditional antibacterial drug in medicine and agriculture， antimicrobial agents and drug-resistant bacteria have flowed into the food production chain which leads to a serious threat to human health. Thus， it is urgent to develop new antibacterial technology. Here， the prevalence of bacteriophage in nature and human environment， the existing human and animal experiments about safety of bacteriophage， and the successful cases and symbolic events of commercialized bacteriophage were summarized. This study also introduced some newly discovered interaction mechanism between bacteriophage and human body， expecting to promote our public cognition about the extensive distribution and safety of oral application of bacteriophage， and promote bacteriophage's commercialized application in the field of food safety.