Improving of Solubilization and in Vitro Release Enhancement of Phloretin by Steviol Glycosides
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    Abstract:

    In order to improve the aqueous solubility of phloretin (PT) in aqueous, steviol glycosides (STE), which can self-assemble to form micelles, was used to prepare steviol glycosides-phloretin micellar(STE-PT MC) complex. At the same time, in vitro release and kinetics of PT alone and PT from STE-PT MC were also investigated. The results showed that STE exhibited significant solubility enhancement on PT and 1.03 g of STE can completely dissolve 30 mg of PT in 10 mL of water under the optimum preparation conditions. STE-PT MC was spherical with an average droplet size of 5.26 nm and without any chemical reaction taken place between STE and PT. In vitro release amounts of PT from STE-PT MC in simulate intestinal fluid and stimulate gastric fluid were 3 to 7 times of that of PT alone. In addition, in vitro release kinetics of PT alone and PT from STE-PT MC were significantly different. The STE-PT MC without any other ingredients addition has a simple preparation process and good practicability in food industry.

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  • Online: April 19,2021
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