Objective： To evaluate the improvement effect of oyster peptide and perilla seed peptide and their combination on sexual function damage in rats through the changes of serum hormone levels， kidney and testis organ index， oxidative stress state and tissue structure changes of kidney and testis. Methods： Preparation of oyster peptide and perilla seed peptide， the amino acid composition and relative molecular mass of the two were detected； rats were injected intraperitoneally with cyclophosphamide to establish a model of sexual function injury， and different doses of peptides and compounding were used to evaluate rat kidneys and testis index， to detect rat serum related indexes， oxidative stress state and tissue structure changes of kidney and testis， and analyze the effect of peptides on the above indexes of model rats. Results： Oyster peptide， perilla seed peptide and compound group can increase the serum index and organ index of model rats to varying degrees， improve the oxidative stress state of kidney and testis and regulate the pathological morphology. Conclusion： Oyster peptide and perilla seed peptide and the compound pair have a certain improvement and regulation effect on the sexual function of rats， the compound effect of the two is better than the single peptide intervention group.