Objective： To investigate the effects of oleanolic acid and ursolic acid， the main components of blueberry cuticular wax， on the resistance of postharvest bluberry to pathogen. Methods： Oleanolic acid and ursolic acid were used to treat dewaxed and waxy intact blueberry respectively， which had inoculated with spore of Botrytis cinerea. Then the disease degree， active ingredients and resistance-related enzyme activity of the blueberry were determined. Results： Oleanolic acid and ursolic acid significantly reduced the decay rate and weight loss rate of dewaxed / waxy intact blueberry， maintained TSS， firmness， VC， total phenol and anthocyanin， and inhibited the increase of TA and MDA. In addition， the activities of peroxidase （POD）， polyphenol oxidase （PPO）， chitinase （CHT） and β-1， 3-glucanase （GLU）， phenylalanine ammonia lyase （PAL） were increased by oleanolic acid and ursolic acid treatment. Conclusion： Oleanolic acid and ursolic acid in cuticular wax of blueberry can improve the postharvest disease resistance and maintain the quality of fruits.