Purpose: To investigate the effect of Xanthoceras sorbifolia leaves extract on blood pressure in spontaneously hypertensive rats (SHR). Methods: Rats were divided into six groups: normal control (rats with normal blood pressure)， positive control (SHR rats fed amlodipine)， negative control (SHR rats)， high， medium and low-dose groups (SHR rats fed 2， 1， 0.5 g/kg Xanthoceras sorbifolia leaves extract). The changes of systolic blood pressure， diastolic blood pressure， mean pressure， heart rate， serum endothelin， NO， total cholesterol and triglyceride were observed after 4 weeks of intragastric administration. Compared with the negative control group， systolic blood pressure， diastolic blood pressure， mean blood pressure and blood lipid of SHR rats in high， medium and low dose groups were significantly decreased (P<0.05)， the middle dose group significantly decreased blood lipid and serum ET-1， increased serum NO level (P<0.05)， but had no significant effect on heart rate and cholesterol in SHR rats (P>0.05). Conclusion: the medium dose group of Xanthoceras sorbifolia leaves extract could significantly reduce the blood pressure of SHR rats.