Objective: To evaluate the immune function of compound astaxanthin. Methods: Splenic lymphocyte transformation test of mice induced by ConA， delayed ear swelling test of mice induced by DNFB， antibody generation cell count test， serum hemolysin generation test， carbon particle clearance test and NK cell activity test were used to comprehensively evaluate the immune-enhancing function of compound astaxanthin. Results: Compared with the solvent control group， astaxanthin oil and compound astaxanthin could significantly improve the proliferation level of splenic lymphocytes and delayed ear edema in mice， and the cellular immune function was positive， and the activity of compound astaxanthin was better than astaxanthin oil. The hemolytic plaque number and serum antibody level were significantly increased， the humoral immune function was positive， and the activity of compound astaxanthin was better than astaxanthin oil. There was no significant effect on carbon clearance and NK cell activity in mice， and the results of mononuclear macrophage function and NK cell activity were negative. Conclusion: The compound astaxanthin has the function of enhancing immunity.