As a medicinal and food resource， Fructus Mori has many biological activities such as antioxidation， hypoglycemic and hypolipidemic. In recent years， as one of its main chemical components， polysaccharides have attracted much attention for their structure， biological activity and function. In this paper， research results reported at home and abroad in recent years were summarized. The extraction and preparation， purification methods， structural characteristics， biological activity and structure-activity relationships of Fructus Mori polysaccharides were systematically reviewed. Finally， personal suggestions for future research and application of Fructus Mori polysaccharides was also put forward.