Effects of Black Wheat Flour on Lipid Metabolism in Hyperlipidemia Rats
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(1.Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences / Hebei Laboratory of Crop Genetics and Breeding / Hebei Research Station of Crop Gene Resource & Germplasm Enhancement,Ministry of Agriculture and Rural Affairs, Shijiazhuang 050035;2.Institute of Cash Crops, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050051;3.The Second Hospital of Hebei Medical University, Shijiazhuang 050000)

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    Abstract:

    Objective: The purpose of the study was to explore the effects of black wheat flour on hypolipidemic action, liver and kidney function of rat with hyperlipidemia, so as to lay the foundation of a dietary therapy for hyperlipidemia. Methods: A total of 50 rats were randomly divided into five groups according to their body weight, 10 rats in each group. The normal control group rats were fed with a standard diet, whereas the other four groups of rats were fed with a high-fat diet to induce dyslipidemia. Hyperlipidemia rats were randomly divided into dyslipidemia control group (DC) and black wheat flour high dose group, middle dose group and low dose group. Rats were fed with corresponding food for 6 weeks, blood lipid levels and body weight of the rats were detected, and the pathological sections of the liver and kidney tissues were observed. Results: 1) The weight-gain-ratio of all dose groups rats were significantly lower than that of the control group rats, and it was significantly lower in black wheat high dose group when compared to the DC group. 2) Compared with before dietary intervention, the blood lipid levels of rats in the three dose groups were significantly reduced, and TC and LDL were lower than that of the DC group, all dose groups serum levels is no statistically difference. 3) The pathological examination showed that the hepatocyte steatosis was at lower level, and renal lesion was alleviated in black wheat all dose groups, compared to the DC. Conclusions: Black wheat flour can lighten the weight of hyperlipidemia rats, ameliorate the lipid metabolism disorder effectively, alleviate the liver and kidney injury caused by hyperlipidemia.

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History
  • Received:June 24,2021
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  • Online: July 19,2022
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