Antarctic krill oil is rich in astaxanthin and unsaturated fatty acids. It is one of the products with high development value in Antarctic krill extract. However， its insoluble water solubility limits its application in food. As a polymer polysaccharide， chitosan is often used as a carrier for some drugs， which can control its release， enhance curative effect， and reduce adverse reactions. In this paper， the response surface optimization method was used to optimize the effects of the three factors of phospholipid-cholesterol ratio， phospholipid-krill oil ratio and chitosan conjugate concentration， and further explore the effects of the optimized product on propylene. Effects of amide-induced oxidative stress on the growth and development of zebrafish embryos. The results showed that under the condition that lecithin ∶ cholesterol is 5 ∶ 1， lecithin ∶ krill oil is 19.6 ∶ 1， and the chitosan mass fraction is 0.146%， the particle size is moderately 145 nm， and the maximum encapsulation efficiency is 98.1%. In addition， it has a significant improvement effect on the inhibition of growth and development caused by oxidative stress damage， and it is dose-dependent within a certain range.