Foodborne diseases caused by foodborne pathogens seriously threaten human health. Sensitive and rapid detection of foodborne pathogens has become an important means to prevent disease occurrence. Biosensors have the advantages of high sensitivity， real-time quantification without enrichment， and easy on-site detection. The combination of CRISPR/Cas system combined with biosensors can improve the sensitivity and accuracy of biosensors detection. This article introduces the classification and mechanism of the CRISPR/Cas system， reviews various biosensors based on CRISPR/Cas for the detection of foodborne pathogens， including fluorescent sensors， electrochemical sensors， and lateral flow strip， and analyzes the advantages and disadvantages of different Cas protein detection， so as to provide reference for the detection of foodborne pathogens.