Using oat-corn-konjac extruded powder， oat bran powder， skimmed milk powder， kudzu root powder， pumpkin powder as basic raw materials， prepared a high dietary fiber powder and explored the effect of obesity intervention on high-fat diet mice. Mice were adaptively fed for 7 days and were divided into blank group， high-fat diet group， experimental group， positive group. After 8 weeks of intragastric administration， the weight， blood glucose， lipid metabolism and tissue sections of the mice were observed and measured. The results showed that compared with the high-fat diet group， high fiber diet could significantly reduce the body weight， abdominal fat weight and fasting blood glucose value of mice(P<0.05)； it could absorb cholesterol， cholesterol and triglyceride content in blood and liver. Compared with the high-fat diet group， liver cholesterol and triglyceride content was reduced by 45.63% and 41.98%， respectively. The meal replacement powder intervention also reduced liver damage caused by high-fat diet， significantly increased serum high-density lipoprotein (P<0.05)， and reduced low-density lipoprotein， aspartate aminotransferase and alanine aminotransferase content. The formula powder in this study can reduce the weight of mice and improve liver damage caused by fat metabolism and obesity.