The protein kinase B is significant serine/threonine protein kinase in eukaryotic cells. It is also a pivotal downstream signal molecule of phosphatidylinositol 3-kinase. Akt can play a crucial role in protein metabolism by regulating the activity of mammalian target of rapamycin， glycogen synthesis kinase 3 or forkhead box； glycogen synthesis or glycolysis can also be regulated by phosphorylation of FoxO and GSK-3. It can also regulate sterol regulatory element-binding transcription factor and mTOR signaling pathway to promote lipid synthesis. In addition， it can phosphorylate FoxO， precursor apoptotic proteins (such as bad， Bcl-2) or Caspase-9 to inhibit the apoptosis pathway and ultimately affects meat quality. In conclusion， Akt and its downstream signaling pathways may be an significant target to improve meat quality. In this article， the activation mechanism and cascade effect of Akt as well as its effect on meat quality were reviewed， with the aim of providing a foundation for improving the meat quality.