Spices can improve the quality， color， flavor and taste of food， and at the same time have a variety of health care functions， which can be used to dispel cold， dehumidify， and dredge meridians. The purpose of this study is to develop a delicious and natural spice drink that can act on the meridians and collaterals by using licorice， cinnamon and ginger， which are sweet and warm in nature， as raw materials. Beverage formulation selection was determined by sensory evaluation by a sensory panel of 6-8 persons. The effect on the meridians was determined by observing the changes in the voltage of the subjects' meridians. The results showed that when the concentration of liquorice was 0 mg/mL， the concentration of cinnamon was 1.5 mg/mL， and the concentration of ginger was 0.5 mg/mL， the sensory evaluation effect of the spice combination beverage was the best. And according to the measurement of the meridian voltage， the ginger-cassia group has the most prominent effect on the meridian voltage of the human body among the 7 different spice combinations (liquorice， cinnamon， ginger， liquorice-cinnamon， liquorice-ginger， ginger-cinnamon， and liquorice-ginger-cinnamon)， can greatly improve the meridian voltage of liver， spleen and kidney meridians， showing that it has a special effect on liver， spleen and kidney meridians.