Background: The consumption of Edible Bird’s Nests (EBN) has a long history. It has been regarded as a high-grade health food and tonic due to its characteristics of high nutritional values and medicinal properties. Although some studies stated that EBN or its active ingredients， sialic acid， has antioxidant effects， there is a lack of studies that systematically investigate the antioxidant effects of EBN. Objective: To systematically evaluate the efficacy of EBN on antioxidant capacity. Method: Relevant studies published between September 1， 2012， and September 1， 2022， were searched and selected using ‘bird nest OR sialic acid’ and ‘antioxidant’ as search terms across China National Knowledge Infrastructure (CNKI)， Wanfang Database， China Biology Medicine disc (CBMdisc)， PubMed and Embase. The selection of relevant studies was guided by predefined inclusion and exclusion criteria. The bias risks of selected studies were based on the SYRCLE's animal research bias risk tool. Result: Six animal model experiments were finally included in total. Results suggested that EBN and sialic acid has a potential role in up-regulating antioxidant activities. EBN or sialic acid may enhance antioxidant capacity by increasing the levels of antioxidants， while simultaneously reducing the occurrence of inflammation and oxidative stress. However， this review did not conduct a meta-analysis. Conclusion: Animal studies indicate a dose-dependent improvement in antioxidant capacity with EBN and sialic acid， but their effects on humans remain uncertain due to the absence of clinical trials.