Furanocoumarins are natural compounds distributed in fruits and vegetables such as citrus， celery， and radish. They have attracted the attention of researchers because of their special biological activity and phototoxicity. Human ingestion or exposure to furanocoumarins along with UVA radiation can cause dermatitis and even cancer in the human body， but it can also be used to treat skin diseases. This article systematically explained the chemical structure of furanocoumarins， distribution in fruits and vegetables， dietary intake， phototoxicity and its application in disease treatment， in order to provide theoretical reference for research on the photoactivity of fruits and vegetables.