Objective: To investigate the intervention effects of slowly digestible starch noodle， acarbose and white kidney bean extract on non-obese diabetic mice induced by streptozotocin (STZ). Methods: A slowly digestible starch noodle with calcium alginate/glucomannan/cornstarch microstructure was studied. The development of in vitro digestion experiments and the characterization of scanning electron microscopy showed that the slowly digestible starch noodle was successfully constructed. The postprandial blood glucose response curve of slowly digestible starch noodles was explored by establishing an animal experimental model of non-obese diabetic mice. Slowly digestible starch noodle， acarbose and white kidney bean extract were used to intervene diabetic mice in different ways for 4 weeks. Fasting blood glucose and body weight of mice in each group were monitored weekly. After 4 weeks of intervention， serum indexes such as FINS， ALT， AST， Urea， CREA， CHOL， TG， HDL-C and LDL-C were measured. At the same time， the histological characteristics of the liver and kidney of each group of mice were observed. Results: Acarbose and slowly digestible starch noodle had a significant effect on glycemic control in diabetic mice (P<0.05)， which could significantly lower blood glucose levels and significantly improve insulin resistance and insulin sensitivity in diabetic mice. However， the side effects of acarbose can result in liver damage in diabetic mice， which is reflected in the significant height of the liver function indicators alanine aminotransferase (ALT) and aspartate transaminase (AST) (P<0.05) and significant liver lesions in liver pathological sections. At the same time， after the intervention of slowly digestible starch noodle in diabetic mice， alanine aminotransferase， aspartate transaminase， urea， creatinine， total cholesterol， triglycerides， high density lipid-cholesterol and low density lipid-cholesterol were closer to normal mice， or there was no significant difference (P>0.05). Compared with acarbose and slowly digestible starch noodle， the intervention effect of white kidney bean extract was worse in different indexes (P<0.05). Conclusion: Slowly digestible starch noodle has a good intervention effect on non-obese diabetic mice， and has no side effects on mice.