Juncao Ganoderma lucidum， which is cultivated with Juncao instead of wood chips， has a wide range of bioactivities and has been shown to have a strong in vitro immune effect. Cyclophosphamide， as an alkylating antitumor agent， is also a typical immunosuppressant that causes immune damage to the body. In the present study， cyclophosphamide-induced immunocompromise model in mice was investigated by gavage of 100 mg/(kg·d) Juncao Ganoderma lucidum alcohol to study the improvement of immune injury in mice. The results showed that JGEH significantly (P < 0.05) increased body weight (6.32%)， organ indices (thymus 38.50%， spleen 71.32%， liver 1.27%， and kidney indices 11.48%)， carbon contouring capacity (41.50%)， and the degree of delayed metamorphosis (59.50%) in mice. In addition， JGEH significantly (P < 0.05) increased immunoglobulin and anti-inflammatory factors， such as IgG (27.73%)， IgA (26.51%)， IgM (23.41%)， and IL-10 (41.98%)， and decreased inflammatory cytokines， such as TNF-α (17.40%)， IFN-γ (17.49%)， and IL-6 (42.33%)， in serum， and significantly (P < 0.05) increased leukocytes (41.23%)， erythrocytes (18.91%)， hemoglobin (42.32%)， platelets (40.29%)， and percentage of lymphocytes (159.94%) in whole blood of mice. Research ideas for the development of alcoholic extracts of the mycorrhizal Juncao Ganoderma lucidum.