Osteopontin stands as one of the abundant functional proteins in human milk. It derived from various mammalian milks， including human milk， has been confirmed to exhibit positive effects on immune balance， intestinal health， and nervous system development in early life. Currently， commercially available milk osteopontin is mainly produced through the separation of bovine milk and has been approved for use in infant formula in some countries and regions. Based on the current scientific researches and applications of milk osteopontin， the relevant experts from clinical medicine， food science， nutrition， and industry representatives were organized by Chinese Institute of Food Science and Technology to form this evidence after literature retrieval， extensive discussions and seminars， which might enhance the scientific understanding of milk osteopontin among the food industry and promote its development in the food industry in our country.