Objective: A metal-organic framework， Cu-MOF， was utilized for the selective extraction of metal-chelating antioxidant peptides from rice protein hydrolysates (RPHs)， enabling one-step directional enrichment of active antioxidant peptides. The enrichment mechanism of rice antioxidant peptides was explored， and their antioxidant properties were evaluated. Methods: Cu-MOF was synthesized via a solvothermal method using Cu2+ as metal center and rigid carboxylic acid H3BTC as ligand. The desorbed metal-chelating peptide mixture was purified using gel filtration chromatography and reverse-phase high-performance liquid chromatography. The structure of the peptides was identified using liquid chromatography-mass spectrometry (LC-MS) and peptide sequence prediction using PepSquencing software. Quantum chemical calculations were performed to predict antioxidant potential of identified peptides. Results: The desorbed fractions demonstrated significant enhancement in free radical scavenging capacities (DPPH: 8.198-fold， ·O₂-: 7.156-fold， ·OH: 19.417-fold， ABTS: 7.060-fold) and Fe2+ chelation ability (1.257-fold)， with ·O₂-/·OH scavenging and Fe2+ chelation capacities comparable to positive controls. Adsorption mechanism involved hydrogen bonding between carboxyl groups in Cu-MOF and amino groups in RPHs. Four peptide sequences were identified: P1 (T-P-G-V-F)， P2 (P-A-C-L-Y)， P3 (Y-L-L-S)， and P4(P-A-E-T-F). Quantum chemical analysis predicted potential antioxidant activity for all four peptides. Conclusion: The extraction of antioxidant peptides from RPHs using the metal-organic framework Cu-MOF represents an efficient method for obtaining rice antioxidant peptides.